Katherine Siminovitch

Canada Research Chair in the Mechanisms Regulating Immunologic Disease

Tier 1 - 2005-03-01
Renewed: 2012-07-01
University of Toronto


Research involves

Defining the molecular mechanisms associated with autoimmune disease.

Research relevance

The research is providing the information needed to develop therapeutic treatments for immunological diseases.

Combating Pain at the Molecular Level

Sufferers of autoimmune diseases, such as inflammatory bowel disease and rheumatoid arthritis, know all too well how urgently improved treatments are needed.

Canada Research Chair Dr. Katherine Siminovitch is dedicated to uncovering the genes underlying these common and painful conditions so these much-needed treatments can be developed.

Using unique mouse models and studies with human patients, this acclaimed research scientist is characterizing the genes that regulate normal immune responses, and defining the mechanisms whereby certain proteins contribute to immune system function and disease development. In addition, she is employing various genetic approaches so she can identify the gene variants responsible for inflammatory bowel disease and rheumatoid arthritis.

Through her research, Dr. Siminovitch is providing insights into the molecular events that predispose people to immunological diseases because she knows that such information is essential for improved therapeutic treatments to be developed.