Marc Servant

Canada Research Chair in Inflammatory Response Signaling

Tier 2 - 2017-11-01
Renewed: 2016-02-01
Université de Montréal
Canadian Institutes of Health Research


Research involves

Understanding innate immune response and investigating its involvement in chronic inflammatory diseases.

Research relevance

This research aims to identify new cellular targets for treating cardiovascular, neoplasic and autoimmune diseases.

Understanding the Role of Inflammation in Disease

Cardiovascular and neoplastic diseases (diseases involving abnormal cell growth) are the leading cause of death and disability in Canada. Despite the progress made to prevent, detect and treat them, these diseases will still kill thousands of Canadians this year and cost the health-care system billions of dollars annually.

It has been shown that inflammation plays an important role in the development of cardiovascular and neoplastic diseases.

As Canada Research Chair in Inflammatory Response Signaling, Dr. Marc Servant is studying specific proteins (kinases and ubiquitin ligases) that regulate innate immune response to diseases such as atherosclerosis and cancer, and cause inflammatory reactions.

Servant’s research combines cell biology, molecular biology, pharmacology, immunology and genetics. With the help of state-of-the-art cell biology techniques and equipment, he aims to identify new cellular targets for treating chronic inflammatory diseases, and to propose new therapy approaches.

By better understanding the role of inflammation in cardiovascular and neoplastic diseases, Servant hopes to improve Canadians’ quality of life and reduce the toll these diseases take on the health-care system.