Mark Glover

Canada Research Chair in Structural Molecular Biology

Tier 1 - 2013-10-01
Renewed: 2020-10-01
University of Alberta
Canadian Institutes of Health Research


Research involves

Examining the systems that protect DNA from damage that can lead to cancer.

Research relevance

This research will provide insight into the mechanisms that protect the genome from damage, and could lead to new cancer therapies.

Research summary

Our DNA is under constant attack from environmental factors—from chemicals to various forms of radiation. To protect genetic information, our bodies have evolved to find systems to repair DNA damage and provide a primary defence against DNA mutations that cause cancer.Dr. Mark Glover, Canada Research Chair in Structural Molecular Biology, aims to improve our understanding of how the genetic information encoded in our DNA is used and maintained within cells. He and his research team are using methods that enable 3D images of DNA to be created while DNA is acted upon by proteins that switch genes on and off and repair damage. Ultimately, they hope to shed light on how the breast cancer-associated protein BRCA1 protects our DNA, and how mutations in this protein affect its function and lead to breast cancer.