Bryan Yipp

Canada Research Chair in Pulmonary Immunology, Inflammation and Host Defence

Tier 2 - 2017-11-01
University of Calgary
Canadian Institutes of Health Research


Coming to Canada From

The Rockefeller University, USA

Research involves

Using advanced imaging technologies to uncover how lung damage develops and how the lung defends against infection.

Research relevance

This research will help develop treatments to defend against lung infections, which are responsible for the deaths of more Canadians than all other infections.

Defending against lung infections

Lung infections kill more Canadians than all other infections and cost the economy billions of dollars every year.

Lung immunity—the lung’s capacity to resist infection—is a complex biological process, involving the integrated and orchestrated function of numerous cells. During a severe infection, innate lung immune cells fight off pathogens, but they can also inadvertently damage surrounding lung tissue, potentially leading to respiratory failure. With few effective drug treatments available in these cases, the only option may be admission to the intensive care unit for advanced mechanical ventilation or life support.

Dr. Bryan Yipp, Canada Research Chair in Pulmonary Imunology, Inflammation and Host Defense, seeks to better understand the development of lung damage and subsequent failure, as well as how the lung coordinates its innate immune cells. 

Using advanced imaging tools, Dr. Yipp studies the coordinated, real-time actions of actual immune cells fighting infection. This allows Dr. Yipp to gain new insights into the coordinated operation of the lung’s immune system.

This research could lead to new treatments to bolster the lung’s immune cells, improving their ability to defend against serious and deadly lung infections.