Research summary
Aging plays a role in the onset of numerous diseases. For example, the chances of getting cancer increase as we get older. This is due to the fact that both aging and cancer can significantly modify the structure and packaging of our genomic DNA, causing cells to lose or acquire new functions that alter their integrity. These epigenetic factors (genetic changes that occur as we age) play a role in the uncontrolled spread of cancer cells and the loss of function of aged cells.
Dr. Frédérick Antoine Mallette, Canada Research Chair in Epigenetics of Aging and Cancer, is investigating the molecular mechanisms underlying epigenetic changes during aging and cancer. Ultimately, he and his research team aim to develop new strategies that will fight cancer and other age-related diseases.