Research summary
The human genome encodes more than 1,500 RNA-binding proteins, many of which can regulate gene expression post-transcriptionally, usually by modulating the splicing and stability of messenger RNA (a type of RNA that is needed for protein production). Abnormalities in these processes have been associated with cancer—yet the regulatory pathways governed by these RNA-binding proteins are among the least-studied aspects of cancer development and progression.
Dr. Hamed Shateri Najafabadi, Canada Research Chair in Systems Biology of Gene Regulation, is trying to understand post-transcriptional networks and their association with cancer. He and his research team are conducting data-driven computational studies to identify cancer-associated post-transcriptional pathways, their connection to the spread of cancer cells, and their role in the emergence of various cell states seen in tumours. Ultimately, their work will support a deeper understanding of complex human diseases.