Research Summary
The brain’s wiring develops throughout life, adapting to new experiences and environments while maintaining core functions like movement. This flexibility—known as neural plasticity—supports learning, memory and recovery from injury. But disruptions to this process can lead to serious disorders. As Canada Research Chair in Brain and Behaviour, Dr. Mei Zhen is studying how genes and the environment shape the assembly, maturation and remodelling of neural circuits.
Zhen’s previous work revealed how the nervous system can compensate for major wiring changes to preserve movement. She identified a genetic mutation that causes a rare condition known as CLIFADD. Now, she and her research team are harnessing advanced imaging, genomics and circuit analysis tools to pinpoint the molecular pathways behind both healthy and abnormal brain development. This knowledge could open the door to new treatments for CLIFADD and other neurological diseases.