DNA encodes genetic information in living organisms. But it can be damaged in a variety of ways, including through environmental influences like UV rays or cigarette smoke. Our brain’s cells, in particular, are exposed to a substantial amount of damage because the organ consumes large amounts of energy. To ensure that DNA conveys genetic data correctly, any damage must be repaired accurately. This happens through complex biological pathways.
To better understand this process, Dr. Galen Wright, Canada Research Chair in Neurogenomics, is using advanced computational approaches to study high-throughput genomic data. Ultimately, he and his research team hope to uncover new insights into the genes and pathways involved in DNA damage response and repair in the brain.