Research summary
Mammals’ brains play a key role in processing information, coordinating behaviours, and supporting learning and problem-solving. But their effective operation depends on the precise production, growth and specialization of neurons during brain development. These processes are regulated by the coordinated actions of many genes—and when gene expression goes awry, neurodevelopmental disorders can result. As Canada Research Chair in Gene Regulation in Brain Development, Dr. Guang Yang is studying how genes are regulated to ensure proper brain development.
He and his research team are focusing on the post-transcriptional control mechanisms that determine the emergence, morphology and identity of neurons in the mammalian cerebral cortex. They are exploring these mechanisms and gaining insights into rare neurodevelopmental disorders in humans. Their work will contribute significantly to the understanding of gene regulation in brain development and human diseases and lead to new ways to diagnose and treat these problems.