Research summary
Biomedical imaging technologies provide a window into the human body. They reveal the spatial patterns of growth and development, the structures of tissues and their chemical compositions, and the functions of organs and body systems.
Dr. John Sled, Canada Research Chair in Biomedical Imaging, has already developed imaging technologies to assess fetal and placental health. Now, he and his research team are developing two new diagnostic technologies—BOLD MRI and wave reflection ultrasound—to identify fetuses most at risk for brain injuries. They are using mouse models of fetal distress to overcome knowledge gaps in interpreting BOLD MRI and identifying the risk of brain injury. They are also developing an advanced form of wave reflection ultrasound to detect placental disease that can cause brain injury or stillbirth. These approaches could help identify at-risk individuals and guide interventions to promote healthy brain development.