Research summary
Computational chemistry uses computer simulation to help solve important problems in chemistry. It is a unique and powerful tool that provides critical information for guiding traditional experimental data. As Canada Research Chair in Computational Chemistry, Dr. Stacey Wetmore is using computer simulations to investigate the chemistry of natural and synthetic modified nucleic acids.
She and her research team are focusing on understanding the cellular roles of transfer RNA modifications in protein synthesis. They are also facilitating the design of aptamer (short, single-stranded DNA or RNA) and small interfering RNA therapeutics. In addition, she and her team are uncovering the function of enzymes that process nucleic acids, thereby assisting nucleic acid development for new applications. Ultimately, their goal is to understand cellular functions that are critical for life and aid the future production of innovative medicines and other technologies.