Improving the Health of Canadians
Genetics and biopharmaceuticals are fast becoming key research fields. Thanks to stem cell research, these fields provide considerable insight into understanding the complex interactions between the environment and human beings, and for developing molecular therapies to treat or prevent certain diseases. As Canada Research Chair in Precursor Proteolysis, Dr. Nabil G. Seidah's is attempting to advance research in these important fields, with particular emphasis on the roles played by certain proteases in age-related diseases and cell dysfunction. Seidah is conducting research in three main areas. First, he is attempting to further advance understanding of the structure and function of pro-protein convertases, as well as their cellular and molecular biology. Furthermore, he is conducting an in-depth analysis of the in vivo functions of pro-protein convertases, using a parallel mouse model / human approach. Finally, he is identifying the physiopathologic roles that convertases play in the development of cardiovascular disease, cancer, viral infections, neurodegenerative diseases and brain dysfunction disorders related to behaviour and development. Seidah’s discoveries should lead to improved therapies and personalized preventative treatments for age-related diseases. This will help improve quality of life for sufferers and reduce the financial burden on our health-care system.