Philpp Lange

Canada Research Chair in Translational Proteogenomics in Pediatric Malignancies

Tier 2 - 2015-10-01
Renewed: 2020-10-01
The University of British Columbia
Canadian Institutes of Health Research

604-875-2000, ext./poste 6015

Research involves

Using genomics, proteomics, bioinformatics and cell biology to study how proteins are modified and interconnected in childhood cancers.

Research relevance

This research will lead to new diagnostic and therapeutic tools for earlier and better treatment of children with cancer.

Research summary

Cancer is the leading cause of disease-related death in Canadian children beyond the newborn period—and even those children who survive cancer will frequently suffer lifelong effects. To improve this situation, Dr. Phillip Lange, Canada Research Chair in Translational Proteogenomics in Pediatric Malignancies, is studying how proteins change in cancer.

He and his research team have discovered specific changes in proteins on cancer cells that hold promise as a new group of anti-cancer targets, and they are investigating the underlying mechanisms. They are also studying how combining genome sequencing with proteome quantification can improve the choice of treatments in precision medicine. Ultimately, they hope to improve cancer therapies by making more treatment choices available and identifying new drug targets.