Liam Brunham

Canada Research Chair in Precision Cardiovascular Disease Prevention

Tier 2 - 2018-01-04
Renewed: 2024-04-01
The University of British Columbia
Canadian Institutes of Health Research

604-682-2344, ext. 63929

Research involves

Using genomics to identify patients at risk of heart disease and improve their care.

Research relevance

This research will lead to new ways to identify patients at risk for heart disease and to safer and more effective ways to treat and prevent this condition.

Research summary

Atherosclerosis, the hardening of the arteries due to a build-up of plaque, is the leading cause of death worldwide. One major risk factor is abnormal levels of plasma lipid (the cholesterol and other fats in our blood). As Canada Research Chair in Precision Cardiovascular Disease Prevention, Dr. Liam Brunham is studying the role of genetic variations in lipid metabolism to better understand this disease.

He and his research team are determining the usefulness of genetic testing for familial hypercholesterolemia (a disorder that prevents the body from removing “bad” cholesterol from the blood) in patients with acute coronary syndrome. They are also establishing a national registry of patients with elevated lipoprotein (a) and studying how the CETP gene influences high-density lipoprotein cholesterol as well as the risk of death from sepsis and severe infections. Ultimately, their research will improve the care of patients with inherited lipid abnormalities, reduce the burden of cardiovascular disease, and identify new treatments for sepsis.