Research summary
Our cells’ ability to interact properly with the extracellular matrix (a network of macromolecules that supports surrounding cells) comes into play during organogenesis (when an embryo’s organs develop) as well as in pathological processes, such as tumour development. As tumours progress, the extracellular matrix stiffens.
Dr. François Bordeleau, Canada Research Chair in Tumor Mechanobiology and Cellular Mechanoregulation, is studying these processes. By uncovering the relationships between tumour progression, molecular and epigenetic changes, and how cells respond to a stiffened tumour environment, he and his research team hope to discover cancer treatments that take advantage of the physical conditions of tumours.