Research Summary
Drug-resistant infections are on the rise—and current lab tests don’t always reflect how bacteria behave inside the human body. Dr. Omar El-Halfawy, Canada Research Chair in Chemogenomics and Antimicrobial Research, is investigating antimicrobial resistance by studying bacteria in environments that closely mimic real infections, revealing survival strategies that are missed in standard tests.
He and his research team are using genomics, high-throughput screening, and drug libraries to find new ways to stop “superbugs,” including repurposing approved medications for faster use. They are also partnering with Indigenous Elders to explore traditional remedies for infections, blending scientific and cultural knowledge to co-develop potential treatments. This research will address a critical global health challenge by identifying new drug targets and improving how antibiotics are used in hospitals. It will also promote Indigenous partnerships and help train the next generation of Canadian scientists in the fight against drug-resistant infections.