Scientists have sequenced many human genomes, revealing significant differences between individuals. But for the most part, we do not know how to use this genomic information to predict how it determines cell, organ and body functions.
In the past, Dr. Brenda Andrews, Canada Research Chair in Systems Genetics and Cell Biology, has used simple yeast cells to better understand human cells and address these challenges. Now, she and her research team are using state-of-the-art cell imaging to generate a complete picture of how genetic variation influences cell function. Ultimately, their research will lay the foundation for building a high-resolution map that will help scientists interpret individual genome variation in the lab and clinic.