Research summary
The dysfunction or loss of oligodendrocytes—glial cells in the central nervous system that produce myelin, the insulating sheath that protects nerve fibres—is thought to be a key driver of neurological impairment. But the specific roles that diseased oligodendrocytes and neural stem cells play in these disorders remain unknown. As Canada Research Chair in Neural Stem Cell Biology, Dr. Anastassia Voronova is uncovering how neural stem cells that harbour pathogenic mutations in genes associated with multiple sclerosis and KBG syndrome (a neurodevelopmental disorder) contribute to these problems.
She and her research team are studying how neural stem cells regenerate the central nervous system, shedding light on their role in neuroinflammation and the development of neurological and neurodevelopmental disorders. They are also examining how these cells can be harnessed for neuroprotection and regeneration. Their work may lead to the discovery of new treatments for disorders like multiple sclerosis.